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KMID : 0390019930030010081
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Pediatric Allergy and Respiratory Disease
1993 Volume.3 No. 1 p.81 ~ p.88
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The changes of ventilatory functions and arterial blood gases before and after salbutamol inhalation in acute attacts of bronchial asthma
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Abstract
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The Changes of ventilatory functions (%FEV1, %V50) and arterial blood gases before and 30 minutes after salbutamol inhalation were examined in 26 cases in moderate groups of acute bronchial asthma with particular reference to correation between
vantilatory functions and arterial blood gases and to influence of arterial oxygen tension. All cases were divied into increased arterial oxygen tension group(I group) and decreased arterial oxygen tension group(D group.
@ES The results were as follows :
@EN 1) The PaO2 after salbutamol inhalation fell down in 13 out of 26(50.0%) and remarkablely decreased more than, 5 mmHg in 7 out of 26(26.9%).
2) The intial value of PaO, had statistically significant positive correlation with initial value of %FEV and %V50. The changes in PaO2 after the inhalation had also positive correlation with initial value of %FEV1 and %V50.
3) Severe patients showed statistically low values of the initial PaO2 and ventilatory functions and showed a fall in PaO2 after inhalation compared with moderate patients.
4) The alteration of PaO2 as a whole, were inverssly rleated to those of (A-a) DO2. There facts suggest that the changes in PaO2 after salbutamol inhalation is mainly result from the alteration of Ventilation/Perfusion ratio.
5) There were no significant changes of pulse rate and symptoms of other side effects of sal butamol inhalation.
In conclusion, salbutamol inhalation is able to exibit a transient worsening of their hypoxemia in acute bronchial asthma. Especially, hypoxamia after salbutamol inhalation shows gradually with incressingly severe stage and decreasingly
ventilatory
functions in acute attacks of bronchial asthma.
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KEYWORD
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